Everything about ceesdekker.net
Everything about ceesdekker.net
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‘Certainly, which is about suitable. I hunt for a physical knowledge of Organic units within a base-up way. I do think you may distinguish 3 strains of study in my group for the time being. The 1st concerns chromosome construction: How would you receive a metre-long DNA polymer folded and organised in this type of microscopic mobile? We have produced visualisation tactics that allow for us to study how, as an example, SMC proteins loop DNA (movie on Youtube) so that you can build up chromosomes.
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, Groningen scientists existing the effects in their endeavours to make labs additional sustainable and supply tricks for other labs.
2007, initially genuine-time detection of strand exchange in homologous recombination by RecA; discovery of the reduced persistence size of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes
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Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is usually that these elements alongside one another make up a residing system. The trick of stated lifetime, I think, lies from the interactions, the interplay of People molecules. The big concern about the origin of daily life is still unanswered. How did we ever evolve from uncomplicated molecules into the really complex programs we see now? We have no idea. I would like to operate on these kinds of huge, open up concerns.’
Nanopores depict a chic and functional Resource to evaluate solitary molecules. We analysis novel detection modes with reliable-condition nanopores along with different strategies to measure proteins with nanopores. Tasks encompass the following:
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There was one issue however — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up basically not such terrific conductors, which was rather disappointing. We Therefore broadened our see to try to discover far more promising molecules.
[14] In 2005 Dekker turned associated with Netherlands-large discussions about Clever Design and style, a motion that he has given that Evidently distanced himself from. Dekker advocates that science and religion will not be in opposition but can be harmonized.
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Example (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in red, in addition to a 3D rendering in the movement in the DNA rod is exhibited.